A new review article published in the journal Trends in Cancer is presenting a promising case for phenformin, an old diabetes drug related to metformin, being repurposed as an adjunct to new immunotherapy cancer treatments. A phase 1 clinical trial is already underway to test the safety of the combination treatment for skin cancer.
Researchers at the Max Planck Institute have demonstrated an intriguing new way to fight cancer by introducing molecular fibers into cells. While harmless to healthy cells, once these fibers encounter the specific environment of cancer cells they assemble into webs, activating the tumor’s self-destruct sequence.
Lately we’ve seen an exciting string of research projects demonstrate how ultrasound can be harnessed to fight cancer, whether that be by helping drugs cross the blood-brain barrier, heating and destroying tissue in prostate cancers, or selectively killing tumor cells while leaving healthy ones unharmed. Adding to this burgeoning potential is a new study that combines ultrasound with microbubbles, which can be blasted apart like a “targeted warhead” to destroy the majority of tumor cells in breast cancer models.
All cells in the human body have a shelf-life, but those of the cancerous variety use some cunning trickery to outlive their expiry dates and continue spreading throughout the body. Scientists at the University of Tokyo have developed a synthetic version of a fungal compound that could help swing things back in our favor, by reactivating a missing gene that would normally drive these sinister cells to self-destruction.
The immune system is already our best defense against cancer, but sometimes it needs help. After all, cancer has a knack for deceiving it and hiding from immune cells, giving itself time to grow and spread. Now, researchers at QIMR Berghofer Medical Research Institute in Australia have identified one way it does so, and found a method to counter it in mouse tests.
Cancer can be a tricky foe, so the best way to fight it might not be with a direct attack, but to cut off its supply lines. One such method, known as gas embolotherapy, involves creating tiny bubbles in the tumor blood vessels, which block the blood supply and starve the cancer out. Now, researchers from China and France have found that the technique could also deal a second blow as a drug delivery system.
One of the many ways scientists are working to unravel the mysteries of Alzheimer’s is by conducting experiments on mice that have been genetically engineered to develop the disease. Researchers pondering the protective potential of compounds found in green tea and carrots have again taken this route and returned some promising results, with the Alzheimer’s mice demonstrating unimpaired cognitive function following a carefully designed bout of treatment.
Over 65 million years ago, an asteroid some 10 km (6 mi) wide crashed into the Earth and wiped out the dinosaurs. Strangely, the legacy of this huge space rock could include a treatment for cancer after scientists from the UK and China demonstrated that iridium – a rare metal delivered to Earth by the asteroid – can be enlisted to kill cancer without harming healthy cells.
Cancer is one of humanity’s biggest killers, but scientists are coming up with some creative ways to fight back. Researchers at the University at Buffalo have developed new kinds of nanoparticles that can infiltrate, heat up and kill cancer cells more effectively and efficiently than similar methods.