Scientists from Osaka City University have found metolazone, an anti-hypertension drug that has been around for almost 50 years, can kickstart a lifespan-extending cellular repair process in roundworms. The research suggests this mechanism could be translatable to humans, offering new research pathways in the search for an anti-aging drug.
Mitochondria are tiny structures that act like cellular power plants. As we age mitochondria become increasingly dysfunctional and, in the search for lifespan-extending medicines, some scientists are looking at ways to repair these fundamental structures.
When mitochondria are damaged a process called mitochondrial unfolded protein response (UPRmt) is sometimes triggered. This mechanism involves the repair of mitochondria, and some anti-aging researchers suspect we could live longer if this process could be activated by taking a drug.
“Even though aging is not a disease, drugs may slow down aging and mitigate or prevent its negative effects on our health,” says Eriko Kage-Nakadai, one of the scientists working on the new research.