Alzheimer’s is a disease with a number of potential causes and therefore a number of potential targets for prevention. One of those centers on a protein call tau, which can gather in long tangles that kill off neurons in the brain. Scientists have developed what they describe as a vaccine to keep the brain clear of these dangerous clumps, and found that treating mice in this way helped stave off the kind of memory decline associated with the disease.
The venom of deadly animals mightn’t seem like a great place to look for life-saving medicines, but scientists are continually sifting through these toxins to discover compounds with huge potential. Now researchers at Stanford studying scorpion venom have identified a pair of compounds that were shown to kill off both staph and tuberculosis bacteria. And better yet, they were able to create synthetic versions in the lab.
Skai made big waves last month with the launch of its long-range hydrogen-powered eVTOL air taxi prototype. In an interview with New Atlas, Skai’s CTO tells us these flying commuter vehicles will cost about the same per mile as an Uber ride, and that he expects to be able to land them just about anywhere.
No matter what the latest fad diet tells us to do, we already know the general gist of how to stay healthy – eating too much sugar and fat leads to weight gain and metabolic diseases. But what if you could stay healthier without changing your diet? In mouse tests conducted at the Max Planck Institute for Metabolism Research, researchers have now found a way to alter the fat metabolism in the liver, reducing the chances of diabetes without changing a high-fat diet.
Our bodies store fat in adipose tissue, but after eating high amounts of the stuff over a long period of time it begins to build up in more important places like the liver. That in turn can lead to fatty liver disease, which can then reduce the body’s response to insulin and eventually bring on type 2 diabetes.
A group of fats known as ceramides have long been associated with these metabolic diseases, and plenty of research has in the past focused on lowering their levels by blocking the proteins that create them – ceramide synthases. Unfortunately, it hasn’t always gone to plan.
“Other research groups have already shown that blocking ceramide production in mice prevents the development of insulin resistance,” says Philipp Hammerschmidt, first author of the new study. “However, this is associated with a large number of side effects. If, for example, ceramide synthesis is completely inhibited it can adversely affect the development of the animals.”
Almost 50 years to the day since Neil Armstrong uttered the immortal words “the Eagle has landed” Lego will launch its Creator Expert set of the Eagle Lunar Module to celebrate the anniversary. Developed in cooperation with NASA, the set comes with mini astronaut figures and a Moon-surface diorama stage complete with craters, footprints, a flag and even a replica of the plaque Armstrong and Aldrin left behind on the surface.
Two fascinating new studies are shedding light on the association between the gut, the brain, and autism. The new research reveals how gastrointestinal problems can be triggered by the same gene mutations associated with autism, and a striking mouse study has demonstrated how a fecal transplant from humans with autism can promote autism-like behaviors in the animals.
Microorganisms like bacteria and fungi are increasingly becoming resistant to our best drugs, which is hurtling us towards a terrifying future where once-easily-treated infections become potentially life-threatening again. In a new approach to this problem, researchers from the University at Buffalo and Temple University have tested an alternative to antibiotics that uses existing drugs to starve a fungal infection of vital nutrients.