A Pill For Your Daily Exercise

Scientists believe we could be closer to  developing a drug that gives us the benefits of exercising without moving a  muscle.

A studies has shown that a compound affected  levels of a protein called REV-ERB in  muscles – which has been shown to boost  metabolism, normalise cholesterol levels and affect how much we  sleep.

Experts hope that the compound could one day  help disabled people get the benefits of exercise without having to  move.

A study has found that a new compound affected levels of a protein called REV-ERB, which has been shown to boost metabolism, normalise cholesterol levels and affect how much we sleep
A study has found that a new compound affected levels of  a protein called REV-ERB, which has been shown to boost metabolism, normalise  cholesterol levels and affect how much we sleep

The study, published this week by researchers  at the Scripps Research Institute in  Florida, found that when their compound was injected  into obese mice, it helped  them lose weight – even if they were on a  high-fat diet – and improved their cholesterol levels,  according to a New York  Times report.

The treated mice also began using more oxygen  throughout the day and expending about 5 per cent more energy than untreated  mice, even though they were not moving about more than the other animals.

This in effect means the compound boosted  their metabolism.

Scripps scientists also worked with  researchers at the Pasteur Institute in France and other institutions, to  discover what their compound might be doing inside muscles to provide this  ‘invisible’ exercise.

Experts have discovered that a compound they formulated affected proteins in the muscles which in turn mimicked an intensive workout
Experts have discovered that a compound they formulated  affected proteins in the muscles which in turn mimicked an intensive  workout

They knew that their drug increased the  potency of the REV-ERB protein, but no one knew what it actually did to muscles.

They therefore developed a strain of mice  that could not express very much of the protein in their muscle  cells.

These animals were what they described as  ‘anti-athletes’.

One of the hallmarks of regular aerobic exercise is that it increases the number and activity of the mitochondria, the cellular structures that help to generate energy while consuming oxygen, in the muscles.

But these animals’ muscles contained very few  mitochondria.

As a result, the animals had diminished  endurance, with a maximam oxygen capacity about 60 percent lower than normal.

They reached exhaustion on treadmill testing  long before their unaffected labmates.

But when, in a separate part of the  experiment, scientists added their compound to isolated muscle cells from the  deficient mice, the cells began pumping out far more REV-ERB.

Those cells, subsequently, began creating  large numbers of new mitochondria and strengthening the existing  ones.

The drug act as an exercise mimic, explained  co-author Thomas Burris, now the chairman of the department of pharmacological  and physiological science at St Louis University School of Medicine.

It is not inconceivable, he added, that at  some point in the future, such a drug might allow people, especially those who  are disabled or can’t otherwise exercise, to enjoy the health benefits of  endurance without the exertion.

Attribution: Rachel Reilly, Mail Online

Joke of the Day

A Blonde’s Year in Review

January – Took new scarf back to store because it was too tight.

February – Fired from pharmacy job for failing to print labels……Helllloooo!!!…..bottles won’t fit in printer!

March – Got really excited…..finished jigsaw puzzle in 6 months…..box said “2-4 years!”

April – Trapped on escalator for hours ? power went out!!!

May – Tried to make Kool-Aid…..wrong instructions….8 cups of water won’t fit into those little packets!!!

June – Tried to go water skiing…..couldn’t find a lake with a slope.

July – Lost breast stroke swimming competition…..learned later, the other swimmers cheated, they used their arms!!!

August – Got locked out of my car in rain storm….car swamped….convertible top left open.

September – The capital of California is “C”….isn’t it?

October – Hate M & M’s…..they are so hard to peel.

November – Baked turkey for 4 1/2 days. Instructions said 1 hour per pound – I weigh 108!!

December – Couldn’t call 911…. “duh”….there’s no “eleven” button on the stupid phone!