Alkahest, a California-based biotech start-up, has just revealed some compelling early results from an ongoing Phase 2 trial into the efficacy of its novel formulation of plasma proteins derived from young blood, developed to slow, or even stop, the cognitive decline associated with Alzheimer’s disease.
Alzheimer’s is a disease with a number of potential causes and therefore a number of potential targets for prevention. One of those centers on a protein call tau, which can gather in long tangles that kill off neurons in the brain. Scientists have developed what they describe as a vaccine to keep the brain clear of these dangerous clumps, and found that treating mice in this way helped stave off the kind of memory decline associated with the disease.
Researchers from the Mayo Clinic have identified a new target in the battle against dementia and age-related cognitive decline – zombie cells. More formally known as senescent cells, these are cells that have stopped dividing but don’t die, and tend to accumulate with age. The new research reveals that many pathological signs of neurodegenerative disease can be eliminated by removing these cells from the brain.
from Sky News:
Patients have been implanted with a tiny “brain pacemaker” in an attempt to slow the progress of Alzheimer’s disease.
The numerous folds which cover our brains change over time, becoming slacker as we age, according to a study.
What’s more, this slacking was seen to be more pronounced in those with Alzheimer’s disease.
Researchers believe that learning more about how the mechanisms which control how folding changes with age could potentially be used to help diagnose brain diseases and spot dementia.
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