Bad News for Alzheimer’s Sufferers

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Biogen has abandoned late-stage clinical trials for a previously promising Alzheimer's drug
Biogen has abandoned late-stage clinical trials for a previously promising Alzheimer’s drug(Credit: AndrewLozovyi/Depositphotos)

A shockwave reverberated through the Alzheimer’s research community today after pharmaceutical company Biogen announced it was discontinuing two massive final phase human trials into the previously promising Alzheimer’s drug aducanumab. The announcement is the latest in a long line of failed Alzheimer’s drugs targeting the popular amyloid protein hypothesis.

2019 is shaping up to be a rough year for Alzheimer’s researchers and pharmaceutical companies. Back in January pharma giant Roche announced it was stopping its major human trials into a drug called crenezumab. Deep into phase 3 trials, and following on from years of study, the early final trial results suggested the drug simply didn’t work to slow, or reverse, the damage from Alzheimer’s disease.

Now, barely two months later, neurological pharma outfit Biogen has pulled the plug on its Alzheimer’s drug. Perhaps even more disappointing than prior negative announcements, aducanumab has been one of the most promising potential Alzheimer’s treatments moving through the pipeline over the past few years.

Aducanumab was developed by examining immune cells from unusually cognitively healthy senior citizens. A particular antibody was isolated that seemed to specifically target the toxic amyloid proteins commonly associated with Alzheimer’s. Early clinical trial results proved exciting, showing the antibody effectively, and safely, cleared amyloid plaques from Alzheimer’s patients, and improved cognitive symptoms.

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About the Common Constitutionalist

Brent, aka The Common Constitutionalist, is a Constitutional Conservative, and advocates for first principles, founders original intent and enemy of progressives. He is former Navy, Martial Arts expert. As well as publisher of the Common Constitutionalist blog, he also is a contributing writer for Political Outcast, Godfather Politics, Minute Men News (Liberty Alliance), Freedom Outpost, the Daily Caller, Vision To America and Free Republic. He also writes an exclusive weekly column for World Net Daily (WND).