A Pill For Your Daily Exercise

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Scientists believe we could be closer to  developing a drug that gives us the benefits of exercising without moving a  muscle.

A studies has shown that a compound affected  levels of a protein called REV-ERB in  muscles – which has been shown to boost  metabolism, normalise cholesterol levels and affect how much we  sleep.

Experts hope that the compound could one day  help disabled people get the benefits of exercise without having to  move.

A study has found that a new compound affected levels of a protein called REV-ERB, which has been shown to boost metabolism, normalise cholesterol levels and affect how much we sleep
A study has found that a new compound affected levels of  a protein called REV-ERB, which has been shown to boost metabolism, normalise  cholesterol levels and affect how much we sleep

The study, published this week by researchers  at the Scripps Research Institute in  Florida, found that when their compound was injected  into obese mice, it helped  them lose weight – even if they were on a  high-fat diet – and improved their cholesterol levels,  according to a New York  Times report.

The treated mice also began using more oxygen  throughout the day and expending about 5 per cent more energy than untreated  mice, even though they were not moving about more than the other animals.

This in effect means the compound boosted  their metabolism.

Scripps scientists also worked with  researchers at the Pasteur Institute in France and other institutions, to  discover what their compound might be doing inside muscles to provide this  ‘invisible’ exercise.

Experts have discovered that a compound they formulated affected proteins in the muscles which in turn mimicked an intensive workout
Experts have discovered that a compound they formulated  affected proteins in the muscles which in turn mimicked an intensive  workout

They knew that their drug increased the  potency of the REV-ERB protein, but no one knew what it actually did to muscles.

They therefore developed a strain of mice  that could not express very much of the protein in their muscle  cells.

These animals were what they described as  ‘anti-athletes’.

One of the hallmarks of regular aerobic exercise is that it increases the number and activity of the mitochondria, the cellular structures that help to generate energy while consuming oxygen, in the muscles.

But these animals’ muscles contained very few  mitochondria.

As a result, the animals had diminished  endurance, with a maximam oxygen capacity about 60 percent lower than normal.

They reached exhaustion on treadmill testing  long before their unaffected labmates.

But when, in a separate part of the  experiment, scientists added their compound to isolated muscle cells from the  deficient mice, the cells began pumping out far more REV-ERB.

Those cells, subsequently, began creating  large numbers of new mitochondria and strengthening the existing  ones.

The drug act as an exercise mimic, explained  co-author Thomas Burris, now the chairman of the department of pharmacological  and physiological science at St Louis University School of Medicine.

It is not inconceivable, he added, that at  some point in the future, such a drug might allow people, especially those who  are disabled or can’t otherwise exercise, to enjoy the health benefits of  endurance without the exertion.

Attribution: Rachel Reilly, Mail Online

About the Common Constitutionalist

Brent, aka The Common Constitutionalist, is a Constitutional Conservative, and advocates for first principles, founders original intent and enemy of progressives. He is former Navy, Martial Arts expert. As well as publisher of the Common Constitutionalist blog, he also is a contributing writer for Political Outcast, Godfather Politics, Minute Men News (Liberty Alliance), Freedom Outpost, the Daily Caller, Vision To America and Free Republic. He also writes an exclusive weekly column for World Net Daily (WND).