No matter what the latest fad diet tells us to do, we already know the general gist of how to stay healthy – eating too much sugar and fat leads to weight gain and metabolic diseases. But what if you could stay healthier without changing your diet? In mouse tests conducted at the Max Planck Institute for Metabolism Research, researchers have now found a way to alter the fat metabolism in the liver, reducing the chances of diabetes without changing a high-fat diet.
Our bodies store fat in adipose tissue, but after eating high amounts of the stuff over a long period of time it begins to build up in more important places like the liver. That in turn can lead to fatty liver disease, which can then reduce the body’s response to insulin and eventually bring on type 2 diabetes.
A group of fats known as ceramides have long been associated with these metabolic diseases, and plenty of research has in the past focused on lowering their levels by blocking the proteins that create them – ceramide synthases. Unfortunately, it hasn’t always gone to plan.
“Other research groups have already shown that blocking ceramide production in mice prevents the development of insulin resistance,” says Philipp Hammerschmidt, first author of the new study. “However, this is associated with a large number of side effects. If, for example, ceramide synthesis is completely inhibited it can adversely affect the development of the animals.”