Get the Fat Out

Scientists have made a major breakthrough in the prevention of heart attacks after developing a vaccine that dramatically reduces fat in the arteries.

The drug, which can be administered by injection or nasal spray, could be available within five years.

Current treatment involves medication that reduces cholesterol and blood pressure.

But the study by Lund University in Sweden is the first which has targeted the underlying cause of heart disease.

Prof Peter Weissberg, the British Heart Foundation medical director, said the vaccine was ‘very promising’.

Fatty deposits can place great strain on the heart by narrowing the arteries and forcing it to pump far harder.

The fatty plaques build up in the blood vessels feeding the heart and over time become narrowed. Parts of the plaque, known as atheroma, may break off causing a clot to form which can block the artery causing a heart attack.

This treatment works by stimulating the body’s immune system to produce antibodies which tackle this build-up.

Working with Prof Prediman Shah, from Cedars-Sinai Heart Institute in Los Angeles, the team were able to formulate a vaccine that reduced plaque build up by 60 to 70 per cent in mice.

 The resulting injection is waiting regulatory clearance to start clinical trials.

The resulting CVX-210 vaccine, currently in development as an injection by CardioVax, is waiting regulatory clearance to start clinical trials.

A second vaccine using the same materials has been formulated as a nasal spray, Prof Nilsson said.

Prof Nilsson said: “The rationale is that since oxidized LDL plays a major role in the development of atherosclerotic plaques and harmful inflammatory processes, directly targeting oxidized LDL should prevent plaque formation and reduce inflammation.”

Early studies have shown that the antibody, called BI-204, developed jointly by BioInvent and Genentech, reduced plaques by half and was well tolerated when tested in 80 healthy people.

A trial of BI-204 in 144 people with heart disease is underway in America and Canada where body scans will measure plaques in the arteries over time. But Prof Jan Nilsson, professor of experimental cardiovascular research at Lund University, said it was unlikely that the drug would be administered like traditional vaccines in childhood.

 ‘The antibody therapy in particularly is likely to be expensive, so you could probably only afford to give it to high-risk populations rather than everyone,’ he told the Daily Telegraph.

Different ways of administering the vaccine are being developed and could be licensed within five years, the Frontiers in CardioVascular Biology conference at Imperial College London was told.

Attribution: Daily Telegraph

Joke du Jour

25 Signs You’ve Grown Up:

Your house plants are alive, and you can’t smoke any of them.

Having sex in a twin bed is out of the question.

You keep more food than beer in the fridge.

6:00 AM is when you get up, not when you go to bed.

You hear your favorite song on an elevator.

You watch the Weather Channel.

Your friends marry and divorce instead of hook up and break up.

You go from 130 days of vacation time to 14.

Jeans and a sweater no longer qualify as “dressed up.”

You’re the one calling the police because those damn kids next door won’t turn down the stereo.

Older relatives feel comfortable telling sex jokes around you.

You don’t know what time Taco Bell closes anymore.

Your car insurance goes down and your payments go up.

You feed your dog Science Diet instead of McDonalds leftovers.

Sleeping on the couch makes your back hurt.

You no longer take naps from noon to 6 PM.

Dinner and a movie is the whole date instead of the beginning of one.

Eating a basket of chicken wings at 3 AM would severely upset, rather than settle, your stomach.

You go to the drug store for ibuprofen and antacid, not condoms and pregnancy tests.

A $4.00 bottle of wine is no longer “pretty good stuff.”

You actually eat breakfast food at breakfast time.

“I just can’t drink the way I used to,” replaces, “I’m never going to drink that much again.”

90% of the time you spend in front of a computer is for real work.

You no longer drink at home to save money before going to a bar.

You read this entire list looking desperately for one sign that doesn’t apply to you!!!

Helen is a Stand-Up Gal

JERUSALEM (The Blaze/AP) — The top Palestinian envoy to the U.S. has honored longtime journalist and former White House correspondent Helen Thomas in an award ceremony.

A Palestinian official says Maen Erekat, the PLO representative in Washington, hosted Thomas at a dinner at his residence.

The storied columnist, who is 91, was forced stepped down two years ago from her job with the Hearst Newspaper chain after video footage emerged showing her outside the White House saying Israelis should “get the hell out of Palestine.”

*Thomas was born of Lebanese immigrants. We all know Israel & Lebanon are not exactly bossom buddies. Maybe that has something to do with her hatred of Israel.

*Doesn’t Helen Thomas, the lover of the United Nations, recall who established Israel in 1948? Of course it was her beloved U.N. Does that mean the U.N. was wrong Helen? Sorry for the digression.

The Palestinian official says the event was to honor Thomas for her “stand against the occupation.” He spoke on condition of anonymity because of what he described as the issue’s sensitivity.

Israel isn’t too happy about the event. Israel’s ambassador to the U.S. Michael Oren told Israeli news outlet Haaretz on Tuesday that it shows the Palestinians don’t want to meet the “basic requisites of peace.”

Oren added he was “appalled by the award ceremony given by the PLO delegation in Washington to Helen Thomas, who has been completely shunned by all decent Americans after making anti-Semitic remarks, along with teaching Palestinian children to hate the Jewish State and to glorify suicide bombers.”

According to a PLO statement obtained by Haaretz, the PLO “presented Thomas with the appreciation and blessing of the president and the Palestinian people, for all of her actions supporting Palestine in the West.”

* Editorial Comments added

Constitution 101 (7)

Lesson 7: “Crisis of Constitutional Government”

Study Guide

Overview:

At the heart of the American constitutional crisis of the mid-nineteenth century stood the moral, social, and political evil of slavery. At stake in this crisis was the future of republican self-government.

Abraham Lincoln saw the dilemma facing the nation as the “crisis of a house divided.” While the American Founders worked to put slavery, as Lincoln said, “on the course of ultimate extinction,” the institution had instead flourished in the first half of the nineteenth century. By the 1850s, efforts to expand slavery threatened to tear the nation apart.

Illinois Senator Stephen Douglas championed the idea that Americans living in the territories should choose whether or not slavery should be legal there. “Popular sovereignty” eventually became the law of the land with the passage of the Kansas-Nebraska Act of 1854, which repealed the Missouri Compromise of 1820.

For Lincoln, “popular sovereignty” was an abandonment of moral principle. Man does not have a moral right to choose a moral wrong. Self-government cannot mean ruling other human beings without their consent. The Kansas-Nebraska Act, although disguised in the language of liberty and self-government, was in fact at odds with the core principles of the American regime.

The Supreme Court’s Dred Scott decision marked a further departure from the principles of the American Founding. Writing for the majority in 1857, Chief Justice Roger Taney declared that the Founders never intended for the principles of natural right enunciated in the Declaration to apply to blacks—whether enslaved or emancipated. Furthermore, Congress had no right to ban slavery in the territories. For Lincoln and the opponents of slavery, this decision was not only constitutionally and historically wrong, but it also further enabled the legal expansion of slavery nationwide.

Lincoln and Douglas debated both popular sovereignty and the Dred Scott decision in their Illinois Senate race of 1858. Douglas maintained that self-government and slavery were compatible and mutually beneficial in certain climates, and it was up to the majority of citizens to determine whether or not the conditions prevailing in their territory or state made slavery useful. Lincoln countered that republicanism and slavery could never exist in harmony, and that self-government could never be compatible with the denial of consent. America, he held, could not long exist half slave and half free; it must become one or the other.

Like it Quiet? Try This

They say silence is golden – but there’s a room in the U.S that’s so quiet it becomes unbearable after a short time.

The longest that anyone has survived in the ‘anechoic chamber’ at Orfield Laboratories in South Minneapolis is just 45 minutes.

It’s 99.99 per cent sound absorbent and holds the Guinness World Record for the world’s quietest place, but stay there too long and you may start hallucinating.

It achieves its ultra-quietness by virtue of 3.3-foot-thick fiberglass acoustic wedges, double walls of insulated steel and foot-thick concrete.

The company’s founder and president, Steven Orfield said,  ‘We challenge people to sit in the chamber in the dark – one reporter stayed in there for 45 minutes.

‘When it’s quiet, ears will adapt. The quieter the room, the more things you hear. You’ll hear your heart beating, sometimes you can hear your lungs, hear your stomach gurgling loudly.

‘In the anechoic chamber, you become the sound.’

And this is a very disorientating experience. Mr Orfield explained that it’s so disconcerting that sitting down is a must.

He said: ‘How you orient yourself is through sounds you hear when you walk. In the anechnoic chamber, you don’t have any cues. You take away the perceptual cues that allow you to balance and manoeuvre. If you’re in there for half an hour, you have to be in a chair.’

The chamber is used by companies all over America – including Nasa, which puts their astronauts to the test in there, floating in a water-filled container, to see ‘how long it takes before hallucinations take place and whether they could work through it’.

As Mr Orfield explains, space is like one giant anechoic chamber, so it’s crucial that astronauts are able to stay focused.

The chamber is also used by a multitude of manufacturers, which test how loud their products are.

Mr Orfield said: ‘It’s used for formal product testing, for research into the sound of different things – heart valves, the sound of the display of a cellphone, the sound of a switch on a car dashboard.’

It’s also put to use to determine sound quality.

Mr Orfield and his team will help companies such as washing-machine maker Whirlpool develop metaphors for what sound should, well, sound like.

Motorcylcle manufacturer Harley-Davidson used the lab, for instance, to make their bikes quieter, while still sounding like Harley-Davidsons.

‘We record products and people listen to them based on semantic terms, like “expensive”, “low quality”, said Mr Orfield. ‘We measure their feelings and associations.’

Mr Orfield admits that he can last a very respectable 30 minutes in the chamber, despite having an off-putting mechanical heart valve that suddenly becomes very loud indeed once he’s inside.

Attribution: Mail Online

Honest…My Dog Ate Them

A desperate golf fan forced his pet pooch to get sick and then sifted through her vomit after she ate his tickets for a prestigious tournament.

Russ Berkman fed his beloved Swiss mountain dog Sierra hydrogen peroxide solution after realizing she had devoured the four sought-after passes to Augusta National, sight of the upcoming Masters golf event .

He then pieced the scraps of the tickets he had won in a lottery back together so he could still fulfill a life-long dream and take his three friends to watch Tuesdays practice round.

He told KJR Radio the first thing he did, when realizing exactly what had been her tasty treat, was ‘panic’.

The Seattle resident then called up his girlfriend, who told him the only thing he could do to get the tickets for the Georgia tournament back undigested was: ‘Well you gotta make the dog puke.’

Feeding her the substance, which is evidently safe for dogs to drink, she quickly threw up her meal.

He added: ‘Quite frankly, she didn’t really have much else in her stomach but that, so it worked out.

‘I grabbed a spatula, put (the vomit) into a Ziploc bag and brought it inside on my kitchen counter.’

‘I started, I guess, either a CSI or surgical-type process to figure out what was going to be salvageable, if anything.’

Each ticket had been chewed into 20 vomit-covered pieces. But he managed to put them back together.

He added: ‘We got about 70 per cent of all four tickets put together. It took about, I don’t know – about three cocktails deep [for me] was how long it took to put this thing all together.’

Then, when he contacted Augusta National Golf Club to explain the situation, they were nice enough to reprint his tickets.

The 2012 tournament begins today, and will see Charl Schwartzel defending his title. Tiger Woods, Phil Mickelson and Rory McIlroy are favorites for this year’s event.

They’re all the Same

The following video is of the famous progressive firebrand, Huey Long. This redistribution speech is from December of 1934, 78 years ago. We all know the old saying, “The more things change, the more they stay the same”. Well, listen carefully to old Huey and tell me it’s not the same speech, with the same villains (new names, but the same villains), such as Big Oil and the rich. Tell me, some 78 years later, this identical speech couldn’t or wouldn’t be given by Obama or any other frothing progressive today. Huey would have received a heros welcome from the ‘Occupy Wallstreet’ crowd.