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Harvard Breaking Down Bacterial Walls

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In this artist's rendition of a bacterium, the blue dots represent the cell wall-building protein RodA...
In this artist’s rendition of a bacterium, the blue dots represent the cell wall-building protein RodA – and disrupting that protein’s function could be key to a new class of antibiotic(Credit: Harvard Medical School)

Bacteria can be hardy little creatures, thanks mostly to their strong cell walls that can protect them against drugs, viruses and other dangers. Finding ways to disarm these defenses is a key component of antibiotics, and now researchers at Harvard Medical School have identified a structural weakness that seems to be built into a range of bacterial species, potentially paving the way for a new class of widely-effective antibacterial drugs.

The new study builds on previous research into a protein named RodA. While the protein itself has long been known, in 2016 the Harvard team was the first to discover that it builds the protective cell walls of bacteria out of sugar molecules and amino acids. Since RodA belongs to the SEDS family of proteins, which is common to almost all bacteria, the team realized it was the perfect target for a far-reaching antibiotic. And on closer examination of RodA, the researchers spotted a vulnerable looking cavity on the outer surface of the protein.

“What makes us excited is that this protein has a fairly discrete pocket that looks like it could be easily and effectively targeted with a drug that binds to it and interferes with the protein’s ability to do its job,” says David Rudner, co-senior author of the study.

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About the Common Constitutionalist

Brent, aka The Common Constitutionalist, is a Constitutional Conservative, and advocates for first principles, founders original intent and enemy of progressives. He is former Navy, Martial Arts expert. As well as publisher of the Common Constitutionalist blog, he also is a contributing writer for Political Outcast, Godfather Politics, Minute Men News (Liberty Alliance), Freedom Outpost, the Daily Caller, Vision To America and Free Republic. He also writes an exclusive weekly column for World Net Daily (WND).

One comment on “Harvard Breaking Down Bacterial Walls

  1. Pingback: Harvard Breaking Down Bacterial Walls – USSA News | The Tea Party's Front Page

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